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KOLSİN Dragee is applied orally.
Run 0.5mg per dragee
Lactose, corn starch, primogel, Ponceau 4R, talc, magnesium stearate, sugar, gum arabic, titanium dioxide, Ewaks
What is KOLSIN and what is it used for?
KOLSİN is presented in the form of a red, round dragee. It contains the active ingredient of colchicine.
KOLSİN is used for the prophylaxis (preventive treatment to prevent the formation or development of the disease) and treatment of acute and chronic gout (drop) disease and familial Mediterranean Fever (abdominal pain, joint pain, swelling and fever) and also Behçet's disease (in the mouth and painful wounds in the genital area, eye problems and skin findings, a disease in which the body creates antibodies against its own cells.
KOLSİN 60 is available in packages containing dragee.
3. How to use KOLSIN?
Instructions for appropriate use and dose / frequency of administration
• Always use KOLSİN as recommended by your doctor. If you are not sure about any situation, please consult your doctor or pharmacist.
• The dose of KOLSİN is adjusted according to the severity of the disease. Use in adults:
Acute gout (also calcium pyrophosphate buildup):
As a preventive (continuously to reduce the frequency and severity of seizures): 1 dragee once a day at the beginning. If necessary, the dose can be increased to 1 dragee twice a day. In mild cases, it may be sufficient to use 1 dragee 1 to 4 times a week.
In case of acute attack: 1 or 2 dragees are taken with the first symptom for treatment. Then, continue with 1 dragee every 1-2 hours until the pain subsides or until nausea, vomiting and diarrhea occur, or until the maximum dose of 6 mg in total (12 dragees) is reached. When the attack passes, drug intake is stopped.
In suppression of familial Mediterranean fever and amyloidosis (a disease caused by the accumulation of amyloid protein in organs):
For protective purposes: Firstly, 1 dragee is given once a day. If necessary and the dose can be tolerated, up to 2 mg per day can be given in divided doses. By dividing into 2 or 3, daily doses can be increased up to a total of 2 mg.
For suppression of acute attack: Start with 1 dragee 4 times, once an hour. Then, it is continued with 1 dragee 2 times every two hours for that day. Then, with 1 dragee application every 12 hours, the treatment is continued for two more days. If the attack is clearly controlled at any time of this three-day treatment, the application can be discontinued.
In Behçet's Disease:
A daily dose of 1-1.5 mg divided by 3 is used.
Application route and method
It is taken orally.
Use in children
Use in the elderly
1 dragee once a day for those younger than 5 years old; 1 dragee twice a day for children 5 years and older.
As the children grow up, the dose may need to be adjusted.
Note: It is reported that children younger than 5 years of age when starting treatment usually require an increase in dose around the age of 7 (increase to 2 dragees per day), and children starting treatment after 5 years of age need a dose increase around the age of 12.5 (3 dragees per day).
It is not known whether KOLSIN is effective and safe in children other than this disease.
Use in the elderly
Your doctor will determine your dose.
Special use cases
In renal failure, the dose of the drug should be changed.
In adults with impaired renal function (creatinine clearance between 10 and 50 ml / min)
For preventive use: 1 dragee once a day.
In the treatment of acute attacks: half the normal dose (no more than 3 mg per day).
If you have kidney failure, you should talk to your doctor.
If you have an impression that the effect of KOLSİN is too strong or too weak, talk to your doctor or pharmacist.
If you use more KOLSIN than you should
If you overdose, symptoms may not appear for 2 to 72 hours. The first symptoms are burning and peeling sensation in the mouth and throat, difficulty swallowing. These symptoms are followed by nausea, vomiting, abdominal pain and diarrhea. Diarrhea can be severe and bloody; There may be pain and torsion in the intestines.
Overdose of KOLSIN may cause dehydration, decrease in blood pressure and shock together with vascular damage. Muscle weakness or paralysis may occur and progress to respiratory failure. Bone marrow damage, damage to the heart muscle can occur.
Liver damage and kidney failure and fluid buildup in the lung may occur. After the 5th day, blood picture disorders occur. Blood in the urine and a decrease in urination are indicators of kidney damage. Muscle weakening and a paralysis may develop. The patient is usually conscious, although seizures may occur. Death can occur as a result of respiratory arrest, cardiac arrest or blood infection.
In surviving patients, hair loss, changes in blood picture and inflammation in the mouth may occur approximately 10 days after overdose.