Estrol Vaginal Cream 1 ML 50 G View larger

Estriol Vaginal Cream 1 ML 50 G


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ESTRIOL Vaginal Cream, 1 mg is applied vaginally or externally.

Active ingredient
1 gram contains 1 mg of estriol.

Yardana ingredients: Decalinium chloride, Perfume oil, Dokusat sodium, Propylene glycol, Dimethicone 350, Glyceryl monostearate, medium chain triglyceride, Softisan 601

1. What is ESTRIOL and what is it used for?

ESTRIOL is a medicinal product belonging to the estrogens group.

ESTRIOL contains estriol.

It is offered for use in aluminum tubes of 35, 50 and 100 grams, together with the applicator and the instructions for use, in a cardboard box.

ESTRIOL is used in the treatment of symptoms caused by estrogen deficiency.
Instructions for appropriate use and dose / frequency of administration:

If it is not recommended otherwise by the physician, the following application method is recommended: The filled form of the practitioner is equivalent to 1 gram of ESTRIOL, which contains 1 mg of estriol.

Vaginal Use

In the presence of systemic (affecting the whole body) and genitourinary (reproductive urinary tract) symptoms due to estrogen deficiency, V2 or 1 applicator load ESTRIOL (corresponding to 0.5 mg or 1 mg estriol) is administered intravaginally for 3 weeks. Afterwards, the treatment is switched to a continuation dose of 0.5 mg (‘A for the applicator) and applied twice a week. Higher doses are not recommended for vaginal administration.

In Patients Undergoing Vaginal Surgery In Pre- and Post-operative Period Treatment: y2 or 1 applicator full of ESTRIOL (equivalent to 0.5 mg or 1 mg estriol) is administered daily, starting two weeks before the surgery. After surgery, 0.5 mg estriol (corresponding to jA applicator) is administered twice a week.

Topical Use,

In the first week of the treatment, a full applicator is applied to the relevant skin area once a day. Then, it is applied 2 or 3 times a week.

2. What are the possible side effects?

Like all medicines, there may be side effects in people who are sensitive to the substances contained in ESTRIOL.

Most undesirable effects occur right at the beginning of the treatment and are dependent on the use of estrogen. If these side effects increase and persist for a few weeks or longer, a physician should be consulted.

Evaluation of side effects is based on the following frequency data.

- Very common: More than 1 in 10 people treated

- Common: More than 1 in 100 people and less than 1 in 10 people treated

- Uncommon: More than 1 in 1000 people and less than 1 in 100 people treated

- Rare: More than 1 in 10,000 people and less than 1 in 1000 people treated

- Very rare: 1 or less of 10,000 people treated, including isolated cases.

Unusual:    .

During long-term use, the lining of the uterus (endometrium) may grow. Breast tenderness, breast pain (especially at the beginning of the treatment), nausea and gastrointestinal complaints (especially at the beginning of the treatment), increased vaginal discharge (especially in the form of excessive cervical discharge), edema (especially at the beginning of the treatment), temporary weight increase and increased blood pressure.

With the vaginal use of a drug containing estriol, an increase in vaginal itching and warmth, burning, redness, irritation may occur, and bleeding in the form of spotting may occur, especially at the beginning.

It may cause skin irritation due to the propylene glycol it contains.


Uterine bleeding, headaches in the form of migraine. Very rare:

Cramping in the legs and a "heavy leg" feeling These are mild side effects of ESTRIOL.
2.Things to watch out for before usingESTRIOL
DO NOT USE ESTRIOL in the following situations

3. Considerations Before Using

S In persons known to be hypersensitive to ESTRIOL or any ingredient in the formulation of the drug,

In case of genital bleeding of unknown cause,

In the presence of an estrogen-sensitive tumor or metastatic (disseminated) tumors, genital bleeding, thrombophlebitis (blood clot formation due to inflammation of the veins), embolic

(vascular occlusion) during diseases,

Current or previous breast cancer history, or

in suspicion,
 Untreated intrauterine thickening (endometrial hyperplasia),
 In severe kidney failure,


USE ESTRIOL CAREFULLY in the following situations

Detailed patient history should be taken before treatment.

The patient should be examined in general and gynecology before treatment and at regular intervals (6-month intervals for long-term treatments) during treatment with ESTRIOL. This is especially true for patients with persistent or recurrent vaginal bleeding.

S Patients should be informed that they should share any changes they observe during treatment (for example, unexpected genital bleeding or changes in the breast) with their doctor.

In the presence of a vaginal infection, the infection should be treated during or before ESTRIOL therapy.