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MINIRIN 0.1 mg / ml nasal spray
1 ml contains 0.1 mg desmopressin acetate equivalent to 89 micrograms of desmopressin.
Sodium chloride, citric acid monohydrate (E330), disodium phosphate dihydrate, benzalkonium chloride, purified water.
MINIRIN Nasal Spray contains 0.1 mg desmopressin acetate in 1 milliliter. 1 dose of spray,
0.1 ml corresponds to 10 micrograms desmopressin acetate. MINIRIN Nasal Spray; antidiuretic hormone (hormone that reduces the amount of urine) is included in the ADH group.
MINIRIN Nasal Spray is available in 2.5 ml or 6 ml in brown glass bottle packaging, which is sprayed with a manual dose pump that does not contain propellant gas.
MINIRIN Nasal Spray is used in the following cases:
• Sugar-free diabetes (Central Diabetes insipidus), excessive thirst and continuous production of dilute urine in large volumes
IMPORTANT: This condition should not be confused with diabetes mellitus (diabetes mellitus and diabetes).
In a test to check whether the kidneys are able to concentrate urine properly (urine concentrating capacity test)
1 dose spray, 0.1 ml corresponds to 10 micrograms desmopressin acetate.
Instructions for appropriate use and dose / frequency of administration
After the test, the dose is determined individually. The normal dose for adults is 10-20 micrograms 1-2 times a day, and 10 micrograms 1-2 times a day for children. If signs of water retention / hyponatraemia occur, treatment should be stopped temporarily and the dose adjusted.
Fluid intake should be restricted. If signs of water retention and / or hyponatraemia (headache, nausea / vomiting, weight gain and, in severe cases, convulsions), treatment should be discontinued until the patient is fully recovered. When treatment is started again, fluid intake should be severely restricted.
Urine concentration capacity test
It is used for diagnostic purposes to determine the urine concentrating capacity. Normal for adults
the dose is 40 micrograms. The dose is 20 micrograms in children older than 1 year, and 10 micrograms in children younger than 1 year.
After administration, Minirin is immediately excreted in the urine within 1 hour. In order to measure osmolality, 2 urine samples are taken in the first 8 hours.
Fluid intake should be restricted.
Application route and method
Note! Before using for the first time, prepare the spray by pressing at least four times or until a smooth spray is obtained.
If the spray has not been used in the last 7 days, you should prepare it for reuse by pressing it several times until a smooth spray is obtained.
IMPORTANT: The bottom of the tube inside the bottle must be immersed in the liquid each time you use the spray (Fig. A).
1. Remove the protective cover.
2. In order for the dose to be adjusted well, the bottle should be kept in the position indicated by the arrow during use.
3. Tilt your head back slightly. Place the tip of the spray in your nostril. Hold your breath while administering the dose. Press once to apply a dose of 10 micrograms.
4. If your doctor has recommended a higher dose, repeat the application in your other nostril. Use individual nostrils for each administration dose.
5. After use, close the protective cover.
Always keep the spray bottle in an upright position.
If in doubt as to whether the correct dose has been taken, do not reapply the spray until the next dose.
Children should use the drug under the supervision and control of adults so that the administered dose can be controlled.
Different age groups
Use in children
In children under 1 year of age, urine concentrating capacity testing should only be performed in hospital under appropriate conditions.
Central diabetes insipidus: The usual dose for children is 10 micrograms 1-2 times a day.
Urine concentration capacity test: The dose is 20 micrograms in children older than 1 year, and 10 micrograms in children younger than 1 year.
Use in the elderly
Elderly patients have a higher risk of hyponatremia (decreased sodium level in the blood).
Central diabetes insipidus: 10-20 micrograms 1-2 times a day.
Urine concentration capacity test: 40 micrograms.
Special use cases
Kidney and liver failure: Special use has not been reported.