75 mg clopidogrel equivalent 97.875 mg clopidogrel hydrogen sulfate
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PLAVIX 75 mg film tablet is taken orally.
Mannitol, lactose, titanium dioxide (El 71) and red iron oxide (E 172), hydrogenated castor oil
• PLAVIX 75 mg is available in blister packs containing 28 and 90 film tablets. Film tablets are light-biconvex, round, film-coated pink tablets with a ”75” face and a yüz 1171 yuvarlak printed face.
The active substance of the PLAVIX tablet is clopidogrel, a class of drugs called antiplatelet drugs. The platelets are smaller than the red and white blood cells and form clusters during blood clotting. Antiplatelet drugs reduce the risk of blood clots by blocking this cluster (the process of formation of the blood clot is called thrombosis).
• PLAVIX is used to prevent the formation of blood clots (thrombi) in hardened blood vessels (arteries). This process is called atherothrombosis and may lead to atherothrombotic events such as stroke, heart attack or death.
Your doctor may have prescribed you PLAVIX for one or more of the following reasons:
- If you have vascular stiffness (atherothrombosis) and if you have
-previously experienced a disease known as heart attack, stroke, or peripheral artery disease,
- "severe unstable angina" called severe chest pain or size myocardial infarction kalp (heart attack). For the treatment of this condition, your doctor may have worn a stent in your narrowed or occluded artery to correct blood flow. In this case, your doctor must have prescribed you acetylsalicylic acid (a drug that prevents blood clotting, as well as pain relief and antipyretic effect in many drugs).
Your doctor will tell you how and at what dose you should use your medication.
Always use the PLAVDC as your doctor told you. If you are not sure how to use the medicine, consult your doctor or pharmacist.
The recommended dose, including the condition called atrial fibrillation (irregular heart rate), is 75 mg of PLAVIX tablets per day and is taken orally, fast or full, at the same time every day. If you have severe chest pain (unstable angina or heart attack), your doctor may prescribe you 300 mg of PLAVIX at the start of the treatment (300 tablets per tablet or 75 rng 4 tablets). The recommended dose is then 75 mg PLAVIX tablets per day, as indicated above.
Take the tablets at the same time every day. Taking your tablets at the same time every day will help you get the most out of your disease. It will also help you remember when to take the tablets.
Be sure to tell your doctor that you are using PLAVIX if a surgical procedure is planned (including dental interventions).
Unless your doctor recommends otherwise follow these instructions.
You should continue taking PLAVDC as long as your doctor prescribes it.
administration Swallow the film tablets at any time during meals or between meals, with enough liquid (1 cup of water).
PLAVIX is not suitable for children and young adults under the age of 18 years. Elderly use No
dosage adjustment is required in older patients. Clopidogrel treatment should be started in patients over 75 years of age with certain types of heart attack (ST elevation acute myocardial infarction) without loading dose.
Allergic cross reactivity: Antiplatelet drugs should be used with caution in patients with hypersensitivity to drugs.
Renal failure: It should be used with caution in patients with renal insufficiency.
Liver failure: It should not be used in severe liver failure. It should be used with caution in mild to moderate hepatic failure.
If you have an impression that the effect of PLAVIX is too strong or too weak, talk to your doctor or pharmacist.
If you have used more than you should use from PLAVIX, talk to a doctor or pharmacist.
As a result of overdose, the risk of bleeding may increase.
If you accidentally received more than one tablet, it is not expected to be anything. If you accidentally take more than one tablet, talk to your doctor or seek medical attention at the nearest hospital's emergency center. If possible, take the tablets or medicine box with you to show the doctor.
you forget to take PLAVIX, PLASTin forgets to take a dose, but if you remember not taking it within 12 hours, swallow your tablet immediately and take the next dose on time.
If you have more than 12 hours after your dose skip, just take the next dose in time. Do not take a double dose of the next dose in order to compensate for ever-forgotten doses.
effects that may occur when treatment with Plavix terminated
If you leave the Plavix treatment without the consent of your doctor, it increases the risk of blood clots in blood vessels. Accordingly, atherothrombotic events such as stroke, heart attack or death may occur.
Like all medicines, PLAVIX may have side effects in people who are sensitive to the substances contained in its contents.
Side effects are listed in the following categories:
Common: Less than one in 10 patients, but more than one in 100 patients.
Uncommon: Less than one in 100 patients, but more than one in 1000 patients. Sparse: Less than one in 1000 patients, but more than one in 10000 patients.
Very rare: less than one in 10,000 patients.
Unknown: Frequency cannot be estimated from existing data
Stop using PLAVIX if you have any of the following and tell your doctor immediately or contact the emergency department of the hospital nearest you
- If fever, symptoms of infection or excessive fatigue occur due to decreased number of rare blood cells
- or if there are liver problems, such as jaundice, in the skin and / or eyes, with or without drowsiness.
- Swelling in the mouth or skin such as itching, rash, blistering. These are symptoms of allergic reaction.
These are all very serious side effects. If you have any of these, you may need emergency medical attention or hospitalization.
edema caused by accumulation of blood in the tissue nosebleeds
stomach or bleeding in the intestine, diarrhea, pain in the upper part of the cam, dyspepsia or
bleeding of the penetrated organs surgical Uncommon
Blood pulcuklann the (thrombocytopenia) and a reduced number of white blood cells (leukopenia, eosinophilia)
Intracranial hemorrhage (death reported in some cases), headache, dizziness, tingling / chills (paresthesia)
Stomach in the mucous membrane of the stomach (stomach ulcer), duodenal ulcer, duodenal ulcer, stomach mucosa inflammation, vomiting, nausea , constipation, bloating Redness, itching, skin bleeding (purpura)
Blood of the urine
Elongation in the bleeding period, decrease in the number of white blood cells called neutrophil, decrease in the number of blood flakes Reduced number of
white blood cells (neutropenia including severe neutropenia) Balance loss and eye blackout transient dizziness accompanied by the vertebrae (vertigo)
Hemorrhage in the outer or posterior part of the abdomen (retroperitoneal hemorrhage)
Gynecomastia (breast growth in males)
Fire, red bruising in the form of a needle head, blurred consciousness, headache and a decrease in the number of platelets (Thrombotic) thrombocytopenic purpura = TTP), a decrease in the formation of blood cells as a result of impaired bone marrow formation (aplastic anemia), deficiency in all cellular structures of the blood (pancytopenia), reduction in the number of white blood cells called granulocytes and as a result, the formation of wounds in the mouth, throat and skin (agranulocytosis), severe decrease in the number of blood platelets (severe thrombocytopenia), decrease in the number of white blood cells called granular leukocytes (granulocytopenia), anemia (anemia)
Fever, urticaria, edema, joint pain, hypersensitivity with symptoms of swelling in the lymph nodes allergic (anaphylactic) reactions
Seeing, hearing, tasting or smelling something that is not present (hallucinations); mind blood elegance
Distortion in the sense of taste
Serious bleeding, bleeding in the wound of the wound, vascular inflammation, low blood pressure
Respiratory bleeding (hemoptysis), narrowing of the bronchi, pneumonia (sometimes cough
accompanied by breathing), eosinophilic pneumonia In the
stomach or intestines hemorrhage, pancreatic inflammation, inflammation of the neck, inflammation of the mouth,
acute liver failure, jaundice, liver function test disorders
, blisters (erythema multiforme, Stevens-Johnson syndrome, toxic
epidermal necrolysis, etc.) and swelling in the throat
(angioedema), hives, drug-induced hypersensitivity syndrome, increased white blood cell count and
DRESS syndrome with systemic symptoms, often itchy with discharge
dermatitis (eczema), especially redness in arm and leg skin (lichen planus), fired
with the body commonly it is infected rash (acute generalized exanthematous pustulosis)
bleeding musculoskeletal system (hemartrosis), joint inflammation, joint pain, muscle pain,
inflammation and destruction with significant renal disease in renal capillaries (glomerulonephritis),
blood creatinine level of
hemophilia A disease with defect in blood clotting
Allergic With the simultaneous use of other drugs effective on PLAVIX and blood flakes
in case of long-lasting bleeding during PLAVIX treatment
When you cut or injure a place, it may take longer than usual to stop the blood. . This is related to the mechanism of action of your medication. This is not important if light cuts and injuries (eg cuts during shaving) are not important. However, if you have any doubts, contact your doctor immediately.
If you are allergic to any of the other ingredients of Clopidogrel or plavix
included,such as stomach ulcers or brain hemorrhage, if you have a medical condition that can cause bleeding
if you have severe liver disease
you have any of the following conditions that could lead to a bleeding risk:
- Medical conditions at risk of internal bleeding (eg stomach ulcer)
- A blood disease that increases the tendency of internal bleeding (tissue, organ or intra-articular hemorrhage in any part of your body)
- a short time passed before the injury
- recently revised surgery (including initiatives related to the teeth)
- 7 day surgery scheduled within (including initiatives related to teeth)
proton pump inhibitor drug group for the treatment of gastric diseases If you have any
liver or kidney disease If your
blood clotting time is prolonged, you may develop a significant hemophilia disease with a disorder in clotting ability. Diagnosis and treatment of this disease should be done under the supervision of a specialist doctor. In this case, treatment with PLAVIX should be stopped.
Co-administration of aspirin and clopidogrel has been shown to increase large bleedings in patients with a recent risk of stroke due to circulatory disorder caused by clotting, and in patients who have recently had such a disorder or stroke. Therefore, it should be cautious to use these two drugs together, except where the benefit is proven.
If a clot has formed in your vein in the last 7 days (ischemic stroke)
You may also show allergic reaction to PLAVIX if you have previously had an allergic reaction to another drug from the same group (eg clopidogrel or prasugrel) (rash, swelling of the throat in the lips, decrease in the number of white blood cells).
When using PLAVIX, inform your doctor about any of the following conditions:
, if any surgery is planned, including
Thrombotic Thrombocytopenic Purpura (TTP)fever, small red spots on the skin due to bleeding under the skin, and / or excessive fatigue, confusion, skin and eye flux. If the medical condition develops with yellowing
If you stop bleeding a little longer than usual when you stop a place If
these warnings apply to you even if you have any history in the past, please consult with your doctor.
PLAVIX is not suitable for use in children and adolescents.
Foods do not affect the absorption of PLDT. PLAVIX can be taken with meals or between meals.
Consult your doctor or pharmacist before using the medicine.
PLAVDT is not recommended for use during pregnancy. If you find yourself pregnant during your treatment, consult your doctor immediately.
Consult your doctor or pharmacist before using the medicine.
It is not recommended to breastfeed your baby while using PLAVIX.
If you are breastfeeding or planning to breastfeed, talk to your doctor before taking PLAce.
PLAVIX is not expected to cause any changes in your ability to.
PLAVIX PLAVIX film coated tablets contain lactose. If you have been told by your doctor that you are not tolerated by some sugars, contact your doctor before using this medicine.
Hydrogenated castor oil in the composition of PLAVIX may cause nausea and diarrhea.
Certain medications may affect the use of PLAVIX or PLAVIX may affect the use of certain drugs.
If you are currently taking any medication, especially one of the medications listed below, or if you recently received medicines, including medication without medication, please inform your doctor or pharmacist about these:
- Oral anticoagulants such as warfarin (medications used to reduce blood clotting): It is not recommended to use this drug with PLAVIX.
- Non-steroidal anti-inflammatory drugs (usually medicinal products used in painful and / or inflammatory conditions of the muscles or joints)
- Heparin or other drugs used to reduce blood clotting drugs
-such as omeprazole, esomeprazole, proton pump inhibitors, drugs included in the drug class or cimetidine (for stomach disorders used drugs
- voriconazole, fluconazole, ciprofloxacin or chloramphenicol (drugs used in the treatment of bacterial and fungal infections)
- fluvoxamine, fluoxetine or moclobemide (drugs used in the treatment of depression)
- carbamazepine, oxcarbazepine (drugs used in the treatment of certain types of)
sarcoma- Ticlopidine, prasugrel ( other antiplatelet drugs)
- Efavirenz (a drug used to treat AIDS)
with Plavix use of such drug is not recommended.
If you use one of these medications, you must tell your doctor.
If you have had severe chest pain (unstable angina or heart attack), your doctor may have prescribed you PLAVIX with acetylcholine silicic acid (acetylsalicylic acid, painkiller, and antipyretics). Short-term use of acetylsalicylic acid (doses not exceeding 1000 mg in a 24-hour period) usually does not lead to a problem, but in other cases, you should consult your doctor in case of prolonged use.
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